Scientific evidence points to A2M (Alpha 2 Macroglobulin) as the key to stopping osteoarthritis at the molecular level. A2M is a Broad Spectrum Multi-Purpose Protease Inhibitor (powerful chemical in destroying proteins that cause arthritis) that captures and inactivates the three major chemicals that lead to joint breakdown and cartilage damage. Once these bad chemicals are trapped by A2M, the body can then quickly eliminate them. It is also reported that A2M can act as a powerful anti-inflammatory and aid in pain management.

Research on IRAP (Interleukin-1 Receptor Antagonist Protein) has shown that it specifically prevents IL-1 from binding to its receptors slowing the progression of osteoarthritis in joints.